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Most patients respond well to a stepped-care approach: physical therapy and medication first, then targeted epidural injections, then minimally invasive options like the MILD procedure or laminectomy if conservative care is not enough

Injectable delivery achieves tissue concentrations 10-20 times higher than topical application

By leveraging these existing therapies, we can explore new, affordable approaches to managing hemolysis, potentially improving patient outcomes and reducing healthcare costs

But the pH has to stay at that level, day after day, month after month, year after year, in order to keep that protective coating strong